Search results for "Neck cancer"

showing 10 items of 126 documents

A quest for initiating cells of head and neck cancer and their treatment.

2010

The biology of head and neck squamous cell carcinomas (HNSCC) and other cancers have been related to cancer stem-like cells (CSC). Specific markers, which vary considerably depending on tumor type or tissue of origin, characterize CSC. CSC are cancer initiating, sustaining and mostly quiescent. Compared to bulk tumors, CSC are less sensitive to chemo- and radiotherapy and may have low immunogenicity. Therapeutic targeting of CSC may improve clinical outcome. HNSCC has two main etiologies: human papillomavirus, a virus infecting epithelial stem cells, and tobacco and alcohol abuse. Here, current knowledge of HNSCC-CSC biology is reviewed and parallels to CSC of other origin are drawn where n…

Cancer ResearchPathologymedicine.medical_specialtymedicine.medical_treatmentepithelial mesenchymal transitionSox2Reviewlcsh:RC254-282NanogMetastasisstemnessSOX2RadioresistancemedicinemetastasisEpithelial–mesenchymal transitionALDH1human papillomavirusbusiness.industryHead and neck cancerCancerchemoresistancelcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogensmedicine.diseaseOct3/4Radiation therapyradioresistancestomatognathic diseasesOncologyCancer researchimmunotherapyStem cellbusinessCancers
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Evolution of oral neoplasm in an andalusian population (Spain)

2018

Background Head and neck cancer are one of the most common neoplasm pathologies in humans. The aim of this study was to analyze the type, characteristics, treatment and evolution of oral neoplasm or precancerous lesion in a sample of Andalusian population (Spain) derived from the Oncology Rehabilitation Hospital Unit during a period of 20 years. Material and Methods A retrospective descriptive study was carried out during the years 1991 and 2011 analyzing the type, characteristics, treatment and follow-up of oral neoplasm in the Oral and Maxillofacial Surgery Unit of the Universitary Hospital “Virgen del Rocío”. The inclusion criteria were patients whose underlying pathology was any type of…

AdultMale0301 basic medicineRehabilitation hospitalmedicine.medical_specialtyTime FactorsPopulationYoung Adult03 medical and health sciences0302 clinical medicineRisk FactorsInternal medicinemedicineHumansYoung adulteducationGeneral DentistryRetrospective Studieseducation.field_of_studybusiness.industryResearchHead and neck cancerRetrospective cohort studyOral NeoplasmMiddle Aged:CIENCIAS MÉDICAS [UNESCO]medicine.disease030104 developmental biologyOtorhinolaryngologyEpidermoid carcinomaSpain030220 oncology & carcinogenesisUNESCO::CIENCIAS MÉDICASOral and maxillofacial surgeryFemaleMouth NeoplasmsSurgeryOral Surgerybusiness
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Quality of life before and after total laryngectomy: Results of a multicenter prospective cohort study

2013

Background The purpose of this study was to determine what quality of life (QOL) areas improve and deteriorate during the first year after total laryngectomy and to identify predictors of these changes. Methods One hundred seventy-four patients completed the European Organization for Research and Treatment of Cancer (EORTC) QOL questionnaires before laryngectomy, n = 133 before discharge from hospital, n = 110 at the end of rehabilitation, and n = 86 1 year after laryngectomy. Multivariate regression analysis was performed to estimate the effect of potential predictors on QOL. Results Areas that did not recover to baseline level were physical functioning, role functioning, social functionin…

Longitudinal studymedicine.medical_specialtyRehabilitationbusiness.industrymedicine.medical_treatmentHead and neck cancermedicine.diseaseMental healthLaryngectomyOtorhinolaryngologyQuality of lifemedicineGlobal healthPhysical therapyProspective cohort studybusinessHead & Neck
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Salivary Cytokines in patients with Head and Neck Cancer (HNC) treated with Radiotherapy.

2019

Background Head and Neck cancer (HNC) is the sixth most common cancer in the world. The 5-year survival rate depends on early diagnosis and appropriate therapy. Typically, late diagnosis requires not only surgical intervention, but also radiotherapy treatment combined or not with chemotherapy. Ionizing radiation is known to increase the expression of a number of cytokines involved in inflammation, wound healing and toxicity areas. Salivary cytokines have promising features to be used as biomarkers for disease screening and outcome prediction in this malignancy. The aim of this article is to analyze the role of salivary inflammatory response elements in HNC patients treated with radiotherapy…

Oncologymedicine.medical_specialtySalivamedicine.medical_treatmentReviewMalignancy03 medical and health sciences0302 clinical medicineInternal medicinemedicineGeneral DentistrySurvival rateChemotherapyOral Medicine and Pathologybusiness.industryHead and neck cancerCancer030206 dentistrymedicine.disease:CIENCIAS MÉDICAS [UNESCO]3. Good healthRadiation therapy030220 oncology & carcinogenesisUNESCO::CIENCIAS MÉDICASBiomarker (medicine)businessJournal of clinical and experimental dentistry
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International validation of the revised European Organisation for Research and treatment of cancer head and neck cancer module, the EORTC QLQ-HN43

2019

Background: We validated the new European Organisation for Research and Treatment of Cancer Quality of Life Head and Neck Module (EORTC QLQ-HN43). Methods: We enrolled 812 patients with head and neck cancer from 18 countries. Group 1 completed the questionnaire before therapy, and 3 and 6 months later. In group 2 (survivors), we determined test–retest reliability using intraclass correlation coefficients (ICC). Internal consistency was assessed using Cronbach's Alpha, the scale structure with confirmatory factor analysis, and discriminant validity with known-group comparisons. Results: Cronbach's alpha was >0.70 in 10 of the 12 multi-item scales. All standardized factor loadings exceeded…

Multimodal therapiesQuality of lifeMalemedicine.medical_specialtySDG 16 - PeacePsychometricsIntraclass correlationMedizinSensitivity and Specificity03 medical and health sciences0302 clinical medicineCronbach's alphaQuality of lifeSurveys and QuestionnairesValidationOutcome Assessment Health CaremedicineHumansProspective Studies030212 general & internal medicineHead and neck cancerReliability (statistics)AgedAged 80 and overbusiness.industryHead and neck cancerSDG 16 - Peace Justice and Strong InstitutionsDiscriminant validityReproducibility of ResultsCancerMiddle Agedmedicine.diseaseCombined Modality Therapy/dk/atira/pure/sustainabledevelopmentgoals/peace_justice_and_strong_institutionsConfirmatory factor analysishumanitiesJustice and Strong Institutions3. Good healthEuropeChemoradiationOtorhinolaryngologyHead and Neck Neoplasms030220 oncology & carcinogenesisQuality of LifePhysical therapyFemalebusinessHead and Neck
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Obstructive Sleep Apnea in Patients with Head and Neck Cancer—More than Just a Comorbidity?

2021

Obstructive sleep apnea is the most common type of sleep-disordered breathing with growing prevalence. Its presence has been associated with poor quality of life and serious comorbidities. There is increasing evidence for coexisting obstructive sleep apnea in patients suffering from head and neck cancer, a condition that ranks among the top ten most common types of cancer worldwide. Routinely, patients with head and neck cancer are treated with surgery, radiation therapy, chemotherapy, immunotherapy or a combination of these, all possibly interfering with the anatomy of the oral cavity, pharynx or larynx. Thus, cancer treatment might worsen already existing obstructive sleep apnea or trigge…

LarynxMedicine (General)Pediatricsmedicine.medical_specialtymedicine.medical_treatmentreviewR5-920Quality of lifemedicineHumansobstructive sleep apneaSleep Apnea Obstructivebusiness.industryPharynxHead and neck cancerCancerGeneral Medicinemedicine.diseaseComorbidityRadiation therapyObstructive sleep apneacomorbiditymedicine.anatomical_structureHead and Neck NeoplasmsQuality of LifeoutcomePharynxhead and neck cancerbusinessMedicina
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GOTeC: INTERDISCIPLINARY TUMOR BOARD FOR THE DIAGNOSIS AND TREATMENTS OF HEAD AND NECK CANCERS

2018

GOTeC DIAGNOSIS TREATMENTS HEAD AND NECK CANCERS
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Melatonin Targets Metabolism in Head and Neck Cancer Cells by Regulating Mitochondrial Structure and Function.

2021

This study was funded by grants from the Ministerio de Economia, Industria y Competitividad y por el Fondo de Desarrollo Regional FEDER, Spain nº SAF2013-49019, SAF2017-85903-P, and from the Consejería de Innovación, Ciencia y Empresa, Junta de Andalucía (P07- CTS- 03135, P10- CTS- 5784, and CTS- 101), Spain. J.F. and L.M. have FPU fellowships from the Ministerio de Educación Cultura y Deporte, Spain. C.R.S. was a schorlarship holder from the Plan Propio de Investigación of the University of Granada.

0301 basic medicine:Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Phosphorylation::Oxidative Phosphorylation [Medical Subject Headings]PhysiologyClinical BiochemistrymelatoninMitochondrionBiochemistryMelatonina:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]0302 clinical medicine:Anatomy::Cells::Cells Cultured::Cell Line [Medical Subject Headings]head and neck cancer cells:Phenomena and Processes::Physiological Phenomena::Pharmacological Phenomena::Drug Resistance::Drug Resistance Neoplasm [Medical Subject Headings]MitophagyMitocondriasChemistryapoptosisglycolysisOXPHOSmitochondria030220 oncology & carcinogenesishormones hormone substitutes and hormone antagonistsmedicine.drug:Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Carbohydrate Metabolism::Glycolysis [Medical Subject Headings]Neoplasias de cabeza y cuello:Diseases::Neoplasms::Neoplasms by Site::Head and Neck Neoplasms [Medical Subject Headings]:Chemicals and Drugs::Inorganic Chemicals::Free Radicals::Reactive Oxygen Species [Medical Subject Headings]Mitofagiafree radicalsOxidative phosphorylationArticleMelatonin03 medical and health sciencesmedicine:Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Growth Processes::Cell Proliferation [Medical Subject Headings]Molecular BiologyRadicales libresCell growth:Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::DNA-Binding Proteins::Receptors Cytoplasmic and Nuclear::Receptors Melatonin [Medical Subject Headings]:Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents [Medical Subject Headings]lcsh:RM1-950:Anatomy::Cells::Cellular Structures::Subcellular Fractions::Mitochondria [Medical Subject Headings]Cell Biologymedicine.diseaseHead and neck squamous-cell carcinoma:Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death::Apoptosis [Medical Subject Headings]Glucólisis030104 developmental biologylcsh:Therapeutics. PharmacologymitophagyApoptosisCancer cellCancer research:Chemicals and Drugs::Hormones Hormone Substitutes and Hormone Antagonists::Hormones::Melatonin [Medical Subject Headings]
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The impact of head and neck radiotherapy on the dentine-enamel junction: a systematic review

2019

Background Radiotherapy is widely used in contemporary head and neck cancer treatment protocols. The ability of head and neck radiotherapy (HNRT) to cause direct radiogenic destruction to the teeth is one of the most controversial topics in the field of oral oncology. Therefore, this systematic review aimed to investigate ionising radiation as an independent factor for physical and chemical changes on the dentine-enamel junction (DEJ), a pivotal dental topography for the onset and progression of radiation-related caries (RRC) and enamel delamination. Material and Methods Systematic searches were conducted on three databases: Scopus, MEDLINE (Via PubMed) and Embase (Elsevier). Laboratory stu…

medicine.medical_treatmentDentistryReviewDental Caries03 medical and health sciences0302 clinical medicinestomatognathic systemHead and neck radiotherapyDentinHumansMedicineDental EnamelMethodological qualityGeneral DentistryOral Medicine and PathologyEnamel paintbusiness.industryHead and neck cancerCancer030206 dentistry:CIENCIAS MÉDICAS [UNESCO]medicine.diseaseQuality of evidenceRadiation therapystomatognathic diseasesmedicine.anatomical_structureOtorhinolaryngologyHead and Neck Neoplasmsvisual_artDentinUNESCO::CIENCIAS MÉDICASvisual_art.visual_art_mediumSurgerybusinessToothMedicina Oral Patología Oral y Cirugia Bucal
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OSTEORADIONECROSIS OF THE JAW AFTER HEAD/NECK RADIOTHERAPY: CAUSES AND MANAGEMENT

2019

Radiation therapy in combination with surgery and chemotherapy is the most common oncologic treatment for head and neck tumors. This combination of different therapies rappresents a successful treatment, however there are adverse side effects, the most severe and serious is the osteroradionecrosis (ORN). The primary treatment for ORN is to prevent its occurrence thus the best preventive procedure is to insert all patients in to a pre-cancer treatment dental protocol.

radioterapy osteoradionecrosis head/neck cancer
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